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mkn 45  (ATCC)


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    ATCC mkn 45
    Mkn 45, supplied by ATCC, used in various techniques. Bioz Stars score: 95/100, based on 58 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/result/mkn 45/product/ATCC
    Average 95 stars, based on 58 article reviews
    mkn 45 - by Bioz Stars, 2026-04
    95/100 stars

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    Novel FRB compounds present antitumor activity. ( A ) IC 50 values of FBR21, FRB24, FRB44 and FRB56 in the glioblastoma (U87), glioma (U251), patient-derived GSC (GNS166), primary human astrocyte (NHA), gastric cancer <t>(MKN45),</t> pancreatic cancer (RWP1) and lung cancer (H1299) cell lines measured by MTT. ( B ) WB of HDAC6 and its target (acetylated α-tubulin) in GNS166-treated cells and U87-treated cells. ( C ) HDAC6, acetylated α-tubulin, HDAC1, acetylated histone 3 and total acetylated lysine protein expression in FRB- and Tubastatin A-treated GNS166 cells and ( D ) U87 cells. ( E ) MAO-A and MAO-B inhibitory capacity of FRBs and reference compounds Clorgiline, Selegiline and Rasalgiline. ( F ) AChE and BChE inhibitory capacity of FRBs and reference compounds Donepezil and Rivastigmine. n.i.: No inhibition.
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    Novel FRB compounds present antitumor activity. ( A ) IC 50 values of FBR21, FRB24, FRB44 and FRB56 in the glioblastoma (U87), glioma (U251), patient-derived GSC (GNS166), primary human astrocyte (NHA), gastric cancer <t>(MKN45),</t> pancreatic cancer (RWP1) and lung cancer (H1299) cell lines measured by MTT. ( B ) WB of HDAC6 and its target (acetylated α-tubulin) in GNS166-treated cells and U87-treated cells. ( C ) HDAC6, acetylated α-tubulin, HDAC1, acetylated histone 3 and total acetylated lysine protein expression in FRB- and Tubastatin A-treated GNS166 cells and ( D ) U87 cells. ( E ) MAO-A and MAO-B inhibitory capacity of FRBs and reference compounds Clorgiline, Selegiline and Rasalgiline. ( F ) AChE and BChE inhibitory capacity of FRBs and reference compounds Donepezil and Rivastigmine. n.i.: No inhibition.
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    Novel FRB compounds present antitumor activity. ( A ) IC 50 values of FBR21, FRB24, FRB44 and FRB56 in the glioblastoma (U87), glioma (U251), patient-derived GSC (GNS166), primary human astrocyte (NHA), gastric cancer (MKN45), pancreatic cancer (RWP1) and lung cancer (H1299) cell lines measured by MTT. ( B ) WB of HDAC6 and its target (acetylated α-tubulin) in GNS166-treated cells and U87-treated cells. ( C ) HDAC6, acetylated α-tubulin, HDAC1, acetylated histone 3 and total acetylated lysine protein expression in FRB- and Tubastatin A-treated GNS166 cells and ( D ) U87 cells. ( E ) MAO-A and MAO-B inhibitory capacity of FRBs and reference compounds Clorgiline, Selegiline and Rasalgiline. ( F ) AChE and BChE inhibitory capacity of FRBs and reference compounds Donepezil and Rivastigmine. n.i.: No inhibition.

    Journal: Pharmaceutics

    Article Title: Generation and Characterization of Novel Contilisant+Tubastatin a Multitarget Small Molecules Against Glioblastoma

    doi: 10.3390/pharmaceutics17121594

    Figure Lengend Snippet: Novel FRB compounds present antitumor activity. ( A ) IC 50 values of FBR21, FRB24, FRB44 and FRB56 in the glioblastoma (U87), glioma (U251), patient-derived GSC (GNS166), primary human astrocyte (NHA), gastric cancer (MKN45), pancreatic cancer (RWP1) and lung cancer (H1299) cell lines measured by MTT. ( B ) WB of HDAC6 and its target (acetylated α-tubulin) in GNS166-treated cells and U87-treated cells. ( C ) HDAC6, acetylated α-tubulin, HDAC1, acetylated histone 3 and total acetylated lysine protein expression in FRB- and Tubastatin A-treated GNS166 cells and ( D ) U87 cells. ( E ) MAO-A and MAO-B inhibitory capacity of FRBs and reference compounds Clorgiline, Selegiline and Rasalgiline. ( F ) AChE and BChE inhibitory capacity of FRBs and reference compounds Donepezil and Rivastigmine. n.i.: No inhibition.

    Article Snippet: U87-MG, U251-MG and NCI-H1299 cells were purchased from ATCC, while MKN45 was obtained from the Leibniz Institute DSMZ-German Collection of Microorganisms and Cell Cultures and the RWP1 cell line was kindly provided by Dr. Francisco Real.

    Techniques: Activity Assay, Derivative Assay, Expressing, Inhibition